By Levels, Committee On Acute Exposure Guideline
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Extra resources for Acute exposure guideline levels for selected airborne chemicals : volume 14.
Response data for BZ were routinely expressed as a CT products (concentration × time) of mg-min/m3. Data points were derived for the lowest and highest exposure durations for which the CT values were determined, as well as for AEGL-specific durations within or near the respective range of the experimental exposure durations. TABLE C-1 Data Used in Category Plot for Agent BZ Source NAC/AEGL-1 Species No. 2 10 AEGL Comments (Continued) Agent BZ (3-Quinuclidinyl Benzilate) 41 TABLE C-1 Continued Source NAC/AEGL-3 Species No.
An estimated median lethal dose (LCt50) for BZ of 200,000 mg-min/m3 was reported by Hoenig (2007), but the basis for that value was not described. 2. Nonlethal Toxicity Ketchum (1963) conducted research on the effects of BZ in male volunteers. Subjects were informed military personnel who underwent medical and psychological evaluations as a prerequisite for participation. Test candidates were also selected on the basis of their evaluation by the Minnesota Multiphasic Personality Inventory and results of psychological interviews.
A modifying factor of 3 was applied because of data deficiencies. Time scaling was performed as described for the AEGL-2 values. AEGL-3 values for the 4-h and 8-h durations are not recommended, because data on longer exposure durations are lacking. AEGL values for BZ are presented in Table 1-1. 1. INTRODUCTION Agent BZ (3-quinuclidinyl benzilate) is an odorless, environmentally stable, white crystalline powder with anticholinergic activity. It was investigated as a potential incapacitating agent for military applications (Ketchum 1963, 2006; Ketchum et al.
Acute exposure guideline levels for selected airborne chemicals : volume 14. by Levels, Committee On Acute Exposure Guideline