Download e-book for kindle: Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

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By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the commonest toxicological goal within the endocrine approach, the adrenal gland has frequently been overlooked in regulatory checking out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts to be had to ascertain adrenal endocrine disruption.

Examining present ideas and the most recent developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the diversity of gear and chemical compounds that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro evaluation. This quantity additionally provides fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the main advancements revamped the previous decade
  • focuses at the most modern learn thoughts, together with their makes use of and limitations
  • provides an built-in procedure for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, supplying impetus for regulatory consideration

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Sample text

Bodart V, Rainey WE, Fournier A, et al. The H295R cell line contains functional atrial natriuretic peptide receptors that inhibit aldosterone biosynthesis. Mol Cell Endocrinol 1996; 118:137–144. Bratusch-Marrain P, Vierhapper H, Waldhausl W, et al. Acute suppressive effects of ACTH induced cortisol secretion on serum prolactin levels in normal men. Acta Endocrinol 1982; 99:352–356. Brooke SM, Sapolsky RM. Glucocorticoid exacerbation of gp120 neurotoxicity: Role of microglia. Exp Neurol 2002; 177:151–158.

Endocrine and Hormonal Toxicology. Chichester: John Wiley, 1999:67–89. Hinson JP, Raven PW. Effects of endocrine-disrupting chemicals on adrenal function. Best Practice and Research Clinical Endocrinology and Metabolism 2006; 20:111– 120. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000; 21:138–167. Hontela A, Rasmussen JB, Audet C, et al. Impaired cortisol stress response in fish from environments polluted by PAHs, PCBs and mercury. Arch Environ Contam Toxicol 1992; 22:278–283.

2005). , 2003), which are standard molecular endocrine challenges. H295R cells also produce aldosterone following angiotensin II stimulation (Kau and Kan, 2005), and aldosterone is a critical and unique hormone of the zona glomerulosa of the adrenal cortex. , 2003). , 2006). , 2006)] and cytokines can also modulate adrenal steroid secretion. Although responsive to ACTH, H295R cells have relatively lower sensitivity to ACTH compared with normal adrenal, attributed to lower level of ACTH receptor expression (ACTH transmits its signal to activate steroidogenesis by a cAMP-dependent pathway), and challenge for steroidogenic capability is affected by forskolin (to activate adenylyl cyclase) or cAMP analogues.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

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